Louisa is a home-rule class city located in eastern Kentucky, United States, at the merger of the Levisa and Tug Forks into the Big Sandy …Louisa is a home-rule class city located in eastern Kentucky, United States, at the merger of the Levisa and Tug Forks into the Big Sandy River, which forms part of the state's border with West Virginia. It is the seat of Lawrence County. The population was 2,467 at the 2010 census and an estimated 2,375 in 2018.
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