Regina is the capital city of the Canadian province of Saskatchewan. The city is the second-largest in the province, and is a commercial centre …Regina is the capital city of the Canadian province of Saskatchewan. The city is the second-largest in the province, and is a commercial centre for southern Saskatchewan. As of the 2021 census, Regina had a city population of 226,404, and a metropolitan area population of 249,217. It is governed by Regina City Council. The city is surrounded by the Rural Municipality of Sherwood No. 159.