Here’s how you can force terminate a hung or not-responding full-screen always-on-top application or game ... a 10-year Microsoft MVP (2006-16) & a Windows Insider MVP (2016-2022).
Keystroke combinations activate the system utility that enables the user to force quit the app. The Windows and Mac key commands are Ctrl-Alt-Del and Command-Option-Escape, respectively.
The Force Quit menu is a simple window, floating above all of your open windows, that shows a list of currently running apps. To force any application to close, click it in the list, then click ...
Sometimes exiting your windows can help, but that isn't always an option when your operating system comes to a complete standstill. When all else fails, you may need to utilize the force quit option.