Every time a shuttle docks with the International Space Station (ISS), a delicate dance unfolds between the shuttle's docking ...

Every time a shuttle docks with the International Space Station (ISS), a precise and intricate process takes place between ...

More information: Namit Chaudhary et al, Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles ...

Ionizable lipid nanoparticles (LNPs) that deliver nucleic acid therapeutics to the liver have been successful in the clinic, but achieving LNP delivery to other organs has been challenging.

One of the most advanced technologies for the delivery of mRNA are lipid nanoparticles (LNPs), which are composed of ionizable lipids, cholesterol, helper lipids and polyethylene glycol.

However, LNPs consisting of helper lipids, PEGylated lipids and ionizable lipids can be susceptible to N-oxide-based impurities that can cause the loss of function of the genetic payload. To ensure ...

Nanomedicine. 2014;9(1):105-120. SNALP & its Application. SNALP is constructed by three basic lipids: an ionizable cationic lipid (1,2-dilinoleyloxy-3-dimethylaminopropane), a neutral helper lipid ...

Specifically, I: (i) implemented a lipid-polymer nanoparticle platform for siRNA delivery to bone marrow endothelial cells in vivo to halt myeloma progression, (ii) developed the first-of-its-kind ...

One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids -- key components of LNPs that change their charge to help them escape the endosome.