A combination of mRNA and a new lipid nanoparticle could help heal damaged lungs, according to new research from the Perelman ...
The structure of CL4F 8-6, the branched ionizable lipid that was most effective in increasing storage stability and LNP-RNA delivery (Image: Yusuke Sato).
LNPs consist of ionizable lipids, which are critical for encapsulating RNA and enabling cellular uptake. Helper lipids contribute to the structural integrity and fusion with cell membranes.
To enhance mRNA distribution, Penn engineers have created an ideal “recipe” for ionizable lipids, essential lipid nanoparticles (LNPs) components, the molecules that underlie COVID-19 vaccines ...
More information: Namit Chaudhary et al, Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles ...
One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids—key components of LNPs that change their charge to help them escape the endosome.
Nanomedicine. 2014;9(1):105-120. SNALP & its Application. SNALP is constructed by three basic lipids: an ionizable cationic lipid (1,2-dilinoleyloxy-3-dimethylaminopropane), a neutral helper lipid ...
However, LNPs consisting of helper lipids, PEGylated lipids and ionizable lipids can be susceptible to N-oxide-based impurities that can cause the loss of function of the genetic payload. To ensure ...