The structure of CL4F 8-6, the branched ionizable lipid that was most effective in increasing storage stability and LNP-RNA delivery (Image: Yusuke Sato).

Every time a shuttle docks with the International Space Station (ISS), a delicate dance unfolds between the shuttle's docking system and its counterpart on the station. Thanks to international ...

LNPs consist of ionizable lipids, which are critical for encapsulating RNA and enabling cellular uptake. Helper lipids contribute to the structural integrity and fusion with cell membranes.

To enhance mRNA distribution, Penn engineers have created an ideal “recipe” for ionizable lipids, essential lipid nanoparticles (LNPs) components, the molecules that underlie COVID-19 vaccines ...

More information: Namit Chaudhary et al, Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles ...

This lipid core provides a hydrophobic environment ideal for encapsulating genetic materials such as messenger RNA (mRNA) or small interfering RNA (siRNA). LNPs typically contain ionizable lipids, ...

Nanomedicine. 2014;9(1):105-120. SNALP & its Application. SNALP is constructed by three basic lipids: an ionizable cationic lipid (1,2-dilinoleyloxy-3-dimethylaminopropane), a neutral helper lipid ...

Specifically, I: (i) implemented a lipid-polymer nanoparticle platform for siRNA delivery to bone marrow endothelial cells in vivo to halt myeloma progression, (ii) developed the first-of-its-kind ...

However, LNPs consisting of helper lipids, PEGylated lipids and ionizable lipids can be susceptible to N-oxide-based impurities that can cause the loss of function of the genetic payload. To ensure ...