Replicating liver fibrosis is a key element in any in vitro NASH model, however, it is normally poorly assessed, unquantifiable and has a limited dynamic range. An advanced three-dimensional (3D) ...

This review provides a detailed examination of experimental mouse models used to study liver fibrosis regression, both in ...

The three key functions of the Core are listed below: These CF mouse models produce no functional Cftr mRNA or protein, and are particularly useful to stufy consequences of the electrophysiological ...

chronic fibrosis at week 12, and HCC after 16 weeks—a course of disease progression very similar to that of human NASH. The STAM mouse model, which emerges against a diabetic background ...

The murine physiology laboratory has developed models that allow the evaluation of genetic interventions in cardiac function, response to load, inflammation, fibrosis and repair. The common strategy ...

We therefore compared the accuracy of simple bedside versus complex fibrosis models across a range of fibrosis in a multi-centre NAFLD cohort. Methods Simple (APRI, BARD) and complex (Hepascore ...

Non-alcoholic steatohepatitis (NASH) resolution with no worsening of fibrosis -- a secondary endpoint -- saw those given VK2809 experiencing NASH resolution ranging from 63% to 75%, compared with ...

On the secondary endpoint of NASH resolution with no worsening of fibrosis, VK2809-treated patients demonstrated NASH resolution ranging from 63% to 75%, compared with 29% for placebo. Across the ...