On this map, the distribution of sickle-cell anemia haplotypes among nations with high prevalence of the disease are shown. Five distinct beta-globin haplotypes (indicated by colors) are found in ...

Doctors noticed that patients who had sickle cell anemia, a serious hereditary blood disease, were more likely to survive malaria, a disease which kills some 1.2 million people every year.

Can we predict that natural selection will weed out genetic disease over time? Sickle-cell trait haplotype distribution shows the genetic advantages of this mutation. In the deoxygenated ...

The UAB Comprehensive Sickle Cell Center brings together scholars and researchers working in the forefront of basic, translational and clinical research, with the overarching goals to discover new ...

In 2007, teams from UAB and the Massachusetts Institute of Technology reported the first successful treatment of sickle cell anemia in experimental animals using induced pluripotent stem (iPS) cells.

Children with sickle cell disease, a chronic hemolytic anemia, present with a wide variety of neurological syndromes, including ischemic and hemorrhagic stroke, transient ischemic attacks ...