and FIB-4 Serum Indexes The relationship between the fibrosis stages and four serum indexes: AAR, APRI, FI and FIB-4 is illustrated in Figure 1 (see also Table 2). There was a significant ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

When fibrosis advances to this point, stage 4, the risk of liver failure is high and an organ transplant is the only remaining treatment option. The Phase 2 test of the Akero drug, efruxifermin ...

Despite new medication, cystic fibrosis often leads to permanent lung damage. Working with an international team, researchers from the Technical University of Munich (TUM) have discovered that the ...

Cystic fibrosis causes early-life changes in the immune system, leading to frequent inflammation that persists despite CFTR modulator therapies. These therapies improve mucus clearance but do not ...