The 49ers will bring a depleted group into Arizona to take on the Cardinals in this NFL odds, prediction, and pick.

It was not a great week for the underdog in Week 17 in the NFL. Only 4 underdogs -- the Chicago Bears, Arizona Cardinals, New York Giants and Jacksonvile Jaguars -- covered the spread and only the Giants and Jaguars won their games outright.

The NFC North title, and the top seed in the NFC for the playoffs, will come down to game 272 of the NFL season as Dan Campbell's Detroit Lions host Kevin O'Connell's Minnesota Vikings on Sunday night.

A win puts the Ravens on top of the AFC North and the No. 3 seed in the conference, and the biggest question for Mike Florio and Chris Simms is Baltimore's margin of victory against the Browns in Week 18.

NFL Week 18 picks, predictions, win probabilities for Chiefs vs Broncos, Vikings vs Lions, Cardinals vs 49ers, Seahawks vs Rams, more games this week.

The Tennessee Titans have achieved true betting infamy this NFL season. At 2-14 against the spread, the Titans currently have the worst against the spread record of any team in the Super Bowl era (the last 59 years) according to ESPN Stats & Information.