Worldwide, approximately 2 million children younger than 15 years of age are infected with multidrug-resistant (MDR) Mycobacterium tuberculosis, with MDR tuberculosis developing in approximately ...

Prevention of drug-resistant tuberculosis is a global health priority. However, trials evaluating the effectiveness of treating Mycobacterium tuberculosis infection among contacts of persons with ...

From August 8, 2018, to January 14, 2020, we vaccinated 265,183 participants. Of these vaccinees, 102,515 were monitored on days 0, 3, and 21 for safety. Among the contacts and contacts-of ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Dr. James Q. Zhou (Medicine): A 56-year-old woman with metabolic dysfunction–associated steatohepatitis and cirrhosis was admitted to this hospital because of end-stage liver disease. The ...

Whether surgical axillary staging as part of breast-conserving therapy can be omitted without compromising survival has remained unclear. In this prospective, randomized, noninferiority trial, we ...

Trials evaluating the effectiveness of treating Mycobacterium tuberculosis infection among contacts of persons with drug-resistant tuberculosis are lacking. New research findings are summarized in ...

Daily insulin injections can be a burden for patients with type 2 diabetes. Insulin efsitora is a new basal insulin that can be given once weekly. New research findings comparing efsitora with ...

This case vignette about a boy with cough, congestion, and fever is accompanied by two essays, one supporting empirical treatment with antibiotics for presumed bacterial pneumonia and the other ...

Depemokimab, an ultra-long-acting biologic agent with enhanced binding affinity for interleukin-5, may improve outcomes in patients with asthma with an eosinophilic phenotype. New research ...

The benefit of percutaneous coronary intervention in patients with stable coronary artery disease undergoing transcatheter aortic-valve implantation for severe aortic stenosis has been unclear.