Here are your top 49ers storylines for Wednesday, November 13th.

The 49ers placed Aiyuk (knee) on injured reserve Wednesday. Aiyuk has a long rehab path ahead of him after suffering ACL and MCL tears in his right knee during Sunday's loss to the Chiefs.

The 49ers designated McCaffrey (Achilles) to return from injured reserve Monday. The move officially opens McCaffrey's 21-day practice window, and he's expected to be on the field Monday.

The Dallas Cowboys (3-4) mounted a fourth-quarter comeback against the San Francisco 49ers (4-4) that gave them the football down six with three minutes left in the game, but they were unable to ...

A rough season for Brandon Aiyuk just got worse. The star San Francisco 49ers receiver, who held out until getting a $120 million extension before the start of the season, was carted off with a ...

When he’d been the quarterback of the 49ers, he’d protested police brutality by kneeling during “The Star-Spangled Banner,” ...

Steve Young, Jerry Rice, Vernon Davis, and an entourage of A-list San Francisco 49ers stars roamed the sidelines before Week 5 a year ago. It was a "who's who" before San Francisco took on the ...

SEATTLE — His beanie could have been a crown. You should have seen Trent Williams after the San Francisco 49ers’ last game, wearing a winter hat with chunky crystals lining the bill.

The star wideout has been hospitalized with a “pneumonia-like illness,” according to 49ers head coach Kyle Shanahan. Samuel, who has 20 receptions for 335 yards and two touchdowns on the ...

And they’ve overcome worse. — Read more from Michael Silver Catch up on what you need to know from this week on the 49ers: Deebo Samuel and George Kittle questionable, Jauan Jennings out ...