Researchers at Tel Aviv University have achieved a breakthrough in drug delivery: they have successfully transported lipid ...

More information: Namit Chaudhary et al, Amine headgroups in ionizable lipids drive ... tailor immune responses when ...

Researchers are mindful of the exciting days when new drugs raised “good” cholesterol, or HDL, but found they didn’t lower the risk of a heart attack or stroke, says Stephen Nicholls ...

Every time a shuttle docks with the International Space Station (ISS), a delicate dance unfolds between the shuttle's docking ...

Lipid nanoparticles (LNPs) are the preeminent drug delivery vehicle for mRNA therapies, partially due to the ionizable lipid (IL) components that facilitate endosomal escape. Here, authors devise ...

Efforts to design new ionizable lipids aim to reduce immune responses and improve the efficiency of drug release within cells. Automating production processes is another focus to meet the increasing ...

Although these drugs can be associated with adverse side-effects, these agents have favorable effects on lipid profiles. However, the need for safer anti-obesity agents is clear.

PEGylated lipids and ionizable lipids can be susceptible to N-oxide-based impurities that can cause the loss of function of the genetic payload. To ensure the safety and efficacy of LNP-based drugs, ...