This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...

Short-chain fatty acids influence gene regulation and chromatin accessibility, highlighting their role in colorectal cancer ...

Morphological profiling allows accurate identification of cell types in dense iPSC-derived cultures, allowing its use for quality control and differentiation monitoring.

These regulators are known as MYB, HDAC2, and FOXA2 and when they were suppressed in colon cancer cells, the cells switched back to a normal-like state, removing the cancer threat without ...

Professor Kwang-Hyun Cho remarked, "The fact that cancer cells can be converted back to normal cells is an astonishing phenomenon. This study proves that such reversion can be systematically induced." ...

Microbial Cell Factories May Help Get to the Root of Understudied Plant Molecules Jan. 16, 2025 — A new tool could make it easier to study scarce plant molecules. Researchers have developed so ...

In cells with signs of degeneration, there were fewer "short-range" connections between chromatin and RNA. The erosion of these intimate interactions meant less contact for genetic translation ...

DNA-containing genes are housed in chromatin, which can be opened or closed to provide access to these instructions. During development, retinal progenitor cells, the precursors to all the ...

The presence of two types of hair cells, the inner and outer hair cells, in the organ of Corti was appreciated nearly a 100 years ago but the function of the two has only become clear in the last 20 ...