Every time a shuttle docks with the International Space Station (ISS), a delicate dance unfolds between the shuttle's docking ...

This lipid core provides a hydrophobic environment ideal for encapsulating genetic materials such as messenger RNA (mRNA) or small interfering RNA (siRNA). LNPs typically contain ionizable lipids ...

Every time a shuttle docks with the International Space Station (ISS), a delicate dance unfolds between the shuttle's docking system and its counterpart on the station.

Here, we use a synthetic amphiphile to modulate the membrane mechanical properties of cell-derived vesicles and probe channel activation. Using precise membrane mechanical characterization approaches ...

Ionizable lipid nanoparticles (LNPs) that deliver nucleic acid therapeutics to the liver have been successful in the clinic, but achieving LNP delivery to other organs has been challenging.

"Dyslipidemia" refers to an abnormality within the lipid profile, encompassing a variety of disorders relating to elevations in total cholesterol, LDL, or TG, or conversely, lower levels of HDL.

Seafront shelters and ornamental lamp columns have been restored as part of a long-running coastal defence scheme. The structures on Southsea promenade in Portsmouth were dismantled and removed ...

Nov. 22, 2024 — Engineers have cooked up a new way to improve mRNA delivery, developing an optimal 'recipe' for ionizable lipids -- key ingredients in lipid nanoparticles (LNPs), the molecules ...

This paper reviews technologies that streamline mRNA vaccine development, from genomic sequencing to lipid nanoparticle (LNP) formulation. We discuss how accurate predictions of neoantigen structures ...