Greg Papa joins "49ers Talk" host Matt Maiocco and discusses if 49ers wide receiver Brandon Aiyuk will step up in Rams ...

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

The 49ers are partly to blame for why Christian McCaffrey will be out at least four games and possibly more as he nurses ...

Kyle Shanahan often couches any comments about the health of his players by noting the obvious: He’s not a doctor. However, ...

ESPN sources: 49ers officially are placing All-Pro RB Christian McCaffrey on injured reserve due to his calf tightness and ...

The 49ers revealed their status reports Friday for their injured players ahead of Sunday’s visit to the Los Angeles Rams.

The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf ...

San Francisco 49ers star tight end George Kittle missed his second straight practice on Friday as ESPN insider Adam Schefter ...

The 49ers revealed their status reports Friday for their injured players ahead of Sunday’s visit to the Los Angeles Rams.

Brock Purdy has faced the Vikings twice in his career. In both games, he turned the ball over twice, led the 49ers to just 17 ...

The San Francisco 49ers are officially listing tight end George Kittle as doubtful to play for their Week 3 divisional ...

Week 3 matchup vs. Rams with key injuries to McCaffrey, Samuel, and Kittle, testing their depth in this crucial NFC West ...