An investigational drug for multiple sclerosis from Io Therapeutics has restored leg mobility and myelin nerve coatings in ...

Much of our knowledge of the protein PD-1, a leading cancer treatment target, comes from studies in mice. In a comprehensive assessment of PD-1, researchers have found that PD-1 in mice is ...

The data suggests that Hmga1, a key protein for regenerating heart cells, could be a target for gene therapies that prevent cardiac failure.

The Ironclaw follows in the footsteps of many Corsair mouse models before it, but it admittedly looks a bit more rugged than its siblings. That’s because it’s designed to fit “most hands ...

For example, certain tumour cell lines may serve as cancer models, and transgenic mice that express human beta-amyloid protein may serve as animal models of Alzheimer’s disease. Through ...

The tool’s performance was consistent across multiple validation cohorts, though accuracy varied slightly, especially when ...

Background and Aim: Inhibition of tumor necrosis factor (TNF)-α is a logical approach to manage patients with non-alcoholic steatohepatitis (NASH ... inflammation and fibrosis was compared.

Though liver biopsy remains the 'suboptimal' gold standard for diagnosis of NASH and staging of fibrosis is essential but not sufficient. Most treatment approaches focus on alleviating the ...

The TMAO producer phenotypes were also reproduced in humanised gnotobiotic mice model. Besides, we found the faecal CntA gene was not associated with TMAO production; therefore, other key relevant ...

Roche’s Genentech unit bought Jecure Therapeutics and its portfolio of NLRP3 drugs in 2018, focusing on peripheral drugs for NASH, liver fibrosis, gout, inflammatory bowel disease, and ...