Key findings from the study include: Enhanced Prime Editing Efficiency with uPEn: The upgraded nuclease prime editor (uPEn) incorporates a ubiquitin variant (i53) to enhance double-strand break (DSB) ...
The N-terminal KH domains equip aCPSF1 with specific-binding capacity to terminator U-tract and the aCPSF1-terminator U-tract cooperation; while the nuclease activity of aCPSF1 was also required for ...
SAMOSA is a high-throughput single-molecule sequencing method that combines adenine methyltransferase footprinting and single-molecule real-time DNA sequencing to natively and nondestructively measure ...
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