Family runs deep in the NFL, and two San Francisco 49ers captains showed that their support extends beyond team colors.

The 49ers A.P.E.X. Employee Resource Group came together to create an apparel line that pays homage to the roots of AAPI ...

The Detroit Lions and San Francisco 49ers play Monday, Dec. 30, at the 49ers' Levi's Stadium in a game on the NFL Week 17 schedule. Which team will win the Monday Night Football game? Check out ...

San Francisco 49ers Head Coach Kyle Shanahan announced the team would start Joshua Dobbs in their season finale at home against the Arizona Cardinals, Dobbs’ former team. Dobbs takes the reigns ...

The 13-2 Detroit Lions travel to San Francisco to play the 6-9 49ers on Monday Night Football one last time before fighting for the division in Week 18. Although the result of this game changes ...

Brock Purdy completed less than half his passes in the first half of last year's NFC championship game. Christian McCaffrey averaged 2.9 yards per carry. George Kittle didn't have a catch.

The San Francisco 49ers are prepping for Week 17 against the Detroit Lions on Monday Night Football. What they're not prepping for is a playoff push in January. At 6-9, Kyle Shanahan and the 49ers ...

The San Francisco 49ers have become the latest team to suffer the dreaded Super Bowl hangover. After a 12-5 season and a third straight NFC Championship game appearance and second Super Bowl ...

The Detroit Lions are heading into a grudge match on Monday Night Football against the San Francisco 49ers, and you can watch the game right here on Channel 7. VIDEO: Barry Sanders talks about ...

A rematch of last year's NFC Championship Game, the Detroit Lions vs. San Francisco 49ers was expected to be one of the best games of the season when the schedule was released. Now though, most ...

It's not the showdown of NFC powers the schedule-makers hoped for back in May, but when the Detroit Lions visit the San Francisco 49ers next Monday night in a rematch of last year's NFC ...