Histone methyltransferase Suv39h1 regulates hepatic stellate cell ...
Objective Liver fibrosis is a prelude to a host of end-stage liver diseases. Hepatic stellate cells (HSCs), switching from a quiescent state to myofibroblasts, are the major source for excessive production of extracellular matrix proteins. In the present study, we investigated the role of Suv39h1, a lysine methyltransferase, in HSC-myofibroblast transition and …
Lamb CA, et al. Gut 2019;68 ...
Oral bacteria accelerate pancreatic cancer development in mice
Objective Epidemiological studies highlight an association between pancreatic ductal adenocarcinoma (PDAC) and oral carriage of the anaerobic bacterium Porphyromonas gingivalis , a species highly linked to periodontal disease. We analysed the potential for P. gingivalis to promote pancreatic cancer development in an animal model and probed underlying mechanisms. Design We tracked P. gingivalis ...
microbiome. review.
Alcohol-associated hepatitis: a neutrophile disease? | Gut
Alcohol-associated hepatitis (AH) is the acute deterioration of alcohol-related liver disease (ArLD) with rapid onset or worsening of jaundice, which, in severe cases, may transition to acute-on-chronic liver failure (ACLF) with extremely high short-term mortality, increasing with the number and severity of hepatic and extra-hepatic organ dysfunction. Systemic inflammation is a hallmark ...
Fungi and cancer - Gut
The microbiome may impact cancer development, progression and treatment responsiveness, but its fungal components remain insufficiently studied in this context. In this review, we highlight accumulating evidence suggesting a possible involvement of commensal and pathogenic fungi in modulation of cancer-related processes. We discuss the mechanisms by which fungi can influence tumour biology ...
Thyroid hormone receptor-beta agonists: new MASLD therapies …
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the leading chronic liver disease worldwide in the past decade.1 The spectrum of liver diseases in MASLD ranges from metabolic dysfunction-associated simple steatosis to steatohepatitis (MASH), advanced fibrosis, cirrhosis and hepatocellular carcinoma. The pathophysiology of MASLD involves many diverse pathways ...
Authors | Gut
When publishing in Gut, authors choose between three licence types – exclusive licence granted to BMJ, CC-BY-NC and CC-BY (Creative Commons open access licences require payment of an article processing charge).As an author you may wish to post your article in an institutional or subject repository, or on a scientific social sharing network.
Intestinal metaplasia and the squamocolumnar junction: what …
May 1, 1998 · See article on page 659 In theory, the diagnosis of Barrett’s oesophagus should be fairly simple, namely the presence of intestinal metaplasia anywhere in the tubular oesophagus. However, recognising where the tubular oesophagus ends and the saccular stomach begins is fraught with difficulty. The precise junction may be difficult to identify endoscopically because of the presence of a hiatus ...
British Society of Gastroenterology guidelines on the management of ... ... The ...