AMPA receptor - Wikipedia
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate and predominantly Na + ion channel that mediates fast synaptic transmission in the central nervous system (CNS).
AMPA receptor structure and auxiliary subunits - PMC
Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA-type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter glutamate. In synapses, AMPAR function is tuned by their auxiliary subunits, a diverse set of membrane proteins associated with the core pore forming subunits of AMPARs.
The role of AMPA receptors in postsynaptic mechanisms of …
In the mammalian central nervous system, excitatory glutamatergic synapses harness neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs).
Structural and Functional Architecture of AMPA-Type Glutamate …
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of excitatory neurotransmission in the central nervous system.
The AMPA receptor as a therapeutic target: current ... - PubMed
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a subtype of the ionotropic glutamate receptors that plays a prominent role in neurotransmission and is widespread throughout the CNS. Because of this, its malfunction can result in a …
AMPARs and Synaptic Plasticity: The Last 25 Years
Oct 10, 2013 · Our goal is to review the major milestones in the field of synaptic plasticity during the past 25 years, with an emphasis on AMPA receptors (AMPARs) and long-term potentiation (LTP). When viewed up close, science, and in particular LTP, appears to progress at …
AMPAR trafficking in synapse maturation and plasticity - PMC
AMPAR trafficking is a key mechanism that drives nascent synapse development, and is the main determinant of both Hebbian and homeostatic plasticity in mature synapses.
AMPA receptor structure and auxiliary subunits - PubMed
Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA-type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter glutamate.
Synaptic AMPA receptor composition in development, plasticity …
Apr 15, 2016 · AMPA receptors (AMPARs) mediate nearly all fast excitatory neurotransmission in the mammalian CNS. AMPARs are heteromeric assemblies of four core subunits, GluA1–4, together with auxiliary...
Visualization of AMPAR Trafficking and Surface Expression
The cell biology of AMPAR synthesis, transport, targeting and surface expression is of crucial importance for correct neuronal function. These processes rely on spatially and temporally coordinated protein-protein interactions to facilitate and regulate receptor trafficking.
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